To meet this demand, KUNPOONG BIO introduces Go2KA1®, a breakthrough, patented, clinically tested nutraceutical designed to define the benchmark for the glucose management category. Go2KA1 is, perhaps, the most advanced, multifunctional nutraceutical ingredient available that helps manage blood sugar levels within the normal range via multiple mechanisms of action:
1) carb control through inhibition of carbohydrate-digesting enzymes as well as 2) enhanced insulin sensitivity. Unlike other ingredients on the market, the inventors of Go2KA1® have developed a “Gold Standard” ingredient that acts comprehensively by helping to promote both effective long-term blood sugar maintenance as well as fast-acting, short-term post-prandial responses.
Advanced Go2KA1® helps promote a healthy glycemic response in a superior, dual-action manner by Go2KA1®
1) helping to control carbohydrate digestion and absorption from the small intestine via inhibition of starch and sugar breakdown, and
2) helping to promote insulin sensitivity via enhancing glucose uptake and metabolism in cells.
Go2KA1 fast-acting properties and ability to control carbohydrates via alpha-glucosidase inhibition were evaluated in a crossover, randomized, placebo-controlled human clinical trial involving 13 healthy subjects
Significant reductions in post-meal blood sugar levels were observed for the Go2KA1® group compared to placebo (Figure 1). Blood glucose was 13% lower in the Go2KA1® group after 30 minutes while the area-under-the-curve (AUC) over the entire 2-hour test period was reduced by 8.8%. The Go2KA1® peak glucose level (Cmax) was significantly lower, and the timing of peak blood sugar (Tmax) was delayed by 40% in the Go2KA1® group (Figure 2).
In this study, healthy subjects took a single 500 mg dose of either Go2KA1or placebo 20 minutes prior to consumption of a single serving of bread (58 g carbohydrates). The postprandial glucose level through oral tolerance test was evaluated in both groups.
As seen in figure 3, Go2KA1® supplementation resulted to significantly lower postprandial blood glucose level compared to placebo group. Blood glucose was 11% lower in the Go2KA1 group after 30 minutes while the area-under-the-curve (AUC) over the entire 2-hour test period was reduced by 6.8%. Finally, the Go2KA1 peak glucose level (Cmax) was significantly lower (8.9%) (Figure 3)
Researchers found that Go2KA1 reduced both long-term blood glucose and post-prandial blood glucose levels in a “Gold Standard”, randomized, double-blind, placebo-controlled human clinical trial of longer duration. 51 healthy subjects took 500 mg of either Go2KA1 or placebo three times daily for 12 weeks After a 12-hour washout period at the end of the study, post-prandial blood sugar was evaluated by giving subjects 75 g of glucose using an Oral Glucose Tolerance Test (OGTT).
Compared to week 0 results, post-meal blood sugar levels in Go2KA1® subjects at week 12 were significantly reduced. Post-meal blood sugar was reduced by 9.1% and 8.6% at 30 minutes and at 60 minutes (Figure 4), AUC over the 2-hour test period was 6% lower, and Cmax was 8.7% less at the end of the study than at week 0.
HbA1c is a scientifically advanced test that measures the average blood glucose level over the previous 12-week period. It is a highly accurate way of evaluating long-term blood sugar maintenance and so is a preferred method used by doctors
As seen in Figure 5, a glycosylated hemoglobin (HbA1c) test was performed at the end of the 12-week clinical trial. Consumption of Go2KA1® resulted in a significant reduction in HbA1c from 6.36 to 6.11 after 12 weeks whereas control group increased the HbA1c level.
Go2KA1 provides the support to a healthy blood sugar balance and helps to enhance insulin sensitivity. Adiponectin is a fat-derived hormone that appears to play a crucial role in protecting against insulin resistance/diabetes. As seen in figure 6, consumption of GO2KA1 enhance the adiponectin concentration significantly in blood after 12 weeks.
Go2KA1 is a patent nutraceutical that possesses the regulatory and scientific substantiation required to dominate in today’s demanding glucose management marketplace. Call us today to learn more about Go2KA1® and how it can add substantial value to your glucose management, healthy weight management, or metabolic wellness product